Treatment Response of PlatinumBased Chemoradiation on Locally Advanced Cervical Cancer

  • Oni Khonsa Faculty of Medicine University of Indonesia/ Dr. Cipto Mangunkusumo Hospital
  • Sigit Purbadi Faculty of Medicine University of Indonesia/ Dr. Cipto Mangunkusumo Hospital
  • Nana Supriana Faculty of Medicine University of Indonesia/ Dr. Cipto Mangunkusumo Hospital
  • Bambang Sutrisna Faculty of Publlic Health University of Indonesia Jakarta

Abstract

Objective: To evaluate the efficacy (treatment response), toxicity, and overall survival of concomitant chemoradiation (CRT) with three-weekly cisplatin-ifosfamide compared to CRT with weekly cisplatin in advanced stage cervical cancers (stage IIB-IIIB). Method: This is a historical cohort between 32 patients receiving CRT with three-weekly cisplatin and ifosfamide and 29 patients receiving weekly cisplatin in Gynecologic Oncology division outpatient clinic and ward, Dr. Cipto Mangunkusumo Hospital. Results: There was no significant difference in treatment response, overall and disease-free survival. There was more gastrointestinal toxicity in the cisplatin-ifosfamide arm compared to the other arm (p=0.014), but other toxicity effects were not different. Conclusion: Platinum based-chemoradiation has the same efficacy in terms of treatment response for locally advanced cervical cancer. [Indones J Obstet Gynecol 2015; 3-4: 212-221] Keywords: cisplatin, concomitant chemoradiation, ifosfamide, locally advance stage cervical cancer

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Author Biographies

Oni Khonsa, Faculty of Medicine University of Indonesia/ Dr. Cipto Mangunkusumo Hospital
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology
Sigit Purbadi, Faculty of Medicine University of Indonesia/ Dr. Cipto Mangunkusumo Hospital
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology
Nana Supriana, Faculty of Medicine University of Indonesia/ Dr. Cipto Mangunkusumo Hospital
Department of Radiotherapy
Bambang Sutrisna, Faculty of Publlic Health University of Indonesia Jakarta
University of Indonesia Jakarta
Published
2015-10-14
Section
Research Article