The Role of Matrix Metalloproteinase2 (MMP2) in Serum and Peritoneal Fluid of Endometriotic Patients

Abstract

Objective: To determine the role of matrix metalloproteinase-2
(MMP-2) in serum and peritoneal fluid of endometriotic
patients.
Methods: Research’s design using cross-sectional method in Dr.
Wahidin Sudirohusodo hospital and several other hospitals in
Makassar within May 2015 until May 2016. Subjects were chosen
using consecutive sampling technique. The examination using
the ELISA method. The data were analysed using Fisher exact,
t-independent, Mann-Whitney, and Spearman association.
Results: A total of 50 subjects were recruited in this study. Mostly
the value of MMP-2 serum and peritoneal fluid in endometriosis
group was higher compare to study control. There was significant
different between the total of MMP-2 serum and peritoneal fluid.
There was also a significant association between the value of
MMP-2 serum and peritoneal fluid with endometriosis.
Conclusion: The value of MMP-2 serum and peritoneal fluid were
higher in endometriotic patients compared to those without
endometriosis. The higher the value of MMP-2 serum and
peritoneal fluid, the higher the stage of endometriosis.
[Indones J Obstet Gynecol 2018; 6-2: 104-109]
Keywords: endometriosis, matrix metalloproteinase-2, MMP-2