Age at Sexual Debut as a Determinant of HPV Infection in Women with  Clinically Normal Cervix in Indonesia

Tofan Widya Utami; Laila  Nuranna; Gatot  Purwoto; Junita  Indarti; Najmarani Devi  Firdaus; Arisda  Oktalia; Nuni  Sulastri; Aria  Kekalih

doi:10.32771/inajog.v14i1.2745

Tofan Widya Utami Obcology Gynecology
Laila Nuranna Departement of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/ RSUPN Cipto Mangunkusumo.
Gatot Purwoto Departement of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/ RSUPN Cipto Mangunkusumo.
Junita Indarti Departement of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/ RSUPN Cipto Mangunkusumo.
Najmarani Devi Firdaus Departement of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/ RSUPN Cipto Mangunkusumo.
Arisda Oktalia Departement of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/ RSUPN Cipto Mangunkusumo.
Nuni Sulastri Departement of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/ RSUPN Cipto Mangunkusumo.
Aria Kekalih Departement of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/ RSUPN Cipto Mangunkusumo.

DOI: https://doi.org/10.32771/inajog.v14i1.2745

Abstract

Objectives: This study examined the association between sexual debut and HPV infection in Indonesian women with a clinically normal cervix, contextualized within the Sustainable Development Goals (SDGs).

Methods: This prospective cohort study utilized primary data from structured interviews and gynecological exams conducted by the Female Cancer Program (FCP) team across public and private health providers in Jakarta (January 2012–July 2018). Cervical cancer risk factors, including early sexual debut, were analyzed using odds ratios (ORs).

Results: A total of 1,390 women with a clinically normal cervix were enrolled in this study, with 52 (3.7%) testing positive for HPV-DNA. Statistical analysis indicated an odds ratio (OR) of 1.176 (95% CI: 0.598–2.316, p = 0.601) for early sexual debut.

Conclusion: This study showed that there was an insignificant association between sexual debut and HPV infection in clinically normal cervix. According to the SDGs, early sexual debut and cervical cancer are highly associated. In order to meet the SDGs by 2030, more research is required to validate this finding and assess additional co-factors connected to cervical cancer.

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