Methylation Profile of HOXA 11 Gene in Eutopic Endometrium on Endometriosis Patient with Infertility

Abstract

Objective: To investigate the HOXA11 gene profile on endometriosis
patients with infertility in Indonesia.
Methods: This cross sectional study was conducted in Dr. Cipto
Mangunkusumo Hospital from July 2015- June 2016. The subjects
were endometriosis patients with infertility who have been
confirmed histopathological. The control group was taken from
non-endometriosis and fertile patients. Eutopic endometrium
samples were taken and examined for the methylation of HOXA 11
gene.
Results: Both groups consist of six patients. The difference of
methylation of HOXA 11 gene between those two groups is
statistically significant (p=0.03). There was hyper methylation in
endometriosis group.
Conclusion: There is a hyper methylation of HOXA 11 gene in
eutopic endometrium of endometriosis patients with infertility.
Thus, possibly can explain the poor endometrial receptivity
in endometriosis patient and give a broad research area in
epigenetic therapy of endometriosis.
[Indones J Obstet Gynecol 2018; 6-2: 110-113]
Keywords: endometriosis, epigenetic, HOXA 11, infertility,
methylation