Low Vitamin D Levels Increase the Risk of Early Onset Neonatal Sepsis

Kadar vitamin D yang Rendah Meningkatkan Risiko Sepsis Neonatal Awitan Dini

  • Lisnawati Yuyun Persahabatan Hospital, Jakarta
  • Ali Sungkar Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital
  • Rinawati Rohsiswatno Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital
  • Noroyono Wibowo Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital
  • Denni Hermartin universities Indonesia
  • Agustin Kindi Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital

Abstract

Abstract

Objective: To identify the association between maternal and umbilical cord vitamin D levels with suspects of early-onset of neonatal sepsis (EONS) in newborns from mothers with preterm premature rupture of membranes (PPROM).
Methods: This is a retrospective cohort study conducted from January 2017 to Augusts 2018. Data was taken consecutively from medical records and previous study data at Dr. Cipto Mangunkusumo and Persahabatan Hospital, Jakarta.
Results: From total of 72 infants from mothers with PPROM, 22 infants (31%) were EONS-suspected and 50 infants (69%) were not EONS-suspected. There was a significant association between maternal and umbilical cord vitamin D levels with EONS.
Conclusion: There was a significant association between maternal and umbilical cord vitamin D levels with EONS.
Keywords: early-onset neonatal sepsis, preterm premature rupture of membrane, vitamin D,

 

Abstrak

Tujuan: Untuk mengetahui hubungan antara kadar vitamin D maternal dan tali pusat dengan risiko tejadinya Sepsis Neonatal Awitan Dini (SNAD) pada bayi dari ibu dengan Ketuban Pecah Dini (KPD).
Metode: Desain penelitian kohort retrospektif secara consecutive sampling. Data diambil dari rekam medis dan data penelitian sebelumnya di Rumah Sakit Umum Pusat Nasional (RSUPN) Dr. Cipto Mangunkusumo dan Rumah Sakit Umum Pusat (RSUP) Persahabatan, Jakarta.
Hasil:  Dari 72 bayi yang dilahirkan dari ibu dengan KPD, 22 bayi (31%) diantaranya diduga mengalami SNAD, sedangkan 50 bayi lainnya tidak mengalami SNAD. Terdapat hubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD.
Kesimpulan:Terdapathubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD.
Kata kunci: ketuban pecah dini,  sepsis neonatal awitan dini, vitamin D

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Author Biographies

Lisnawati Yuyun, Persahabatan Hospital, Jakarta

Department of Obstetrics and Gynecologi

Ali Sungkar, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital

Department of Obstetrics and Gynecology

Rinawati Rohsiswatno, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital

Department of Pediatric

Noroyono Wibowo, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital

Department of Obstetrics and Gynecology

Agustin Kindi, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital

Departement of Obstetrics and Gynecology

Published
2020-04-30
Section
Research Article